University of Wisconsin-Madison UW-Madison

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Corinne Engelman

Professor of Population Health Sciences

Population Health Sciences

Study design and data analysis of genetic, metabolomic, demographic, socioeconomic, behavioral, physiological and environmental factors of biomarkers and preclincal traits related to Alzheimer’s disease.

Phone

(608) 265-5491

Email

cengelman@wisc.edu

Website

https://engelmanlab.pophealth.wisc.edu/

Office Location

Room 1007a WARF Office Building
610 Walnut Street
Madison, WI 53726

Dr. Engelman earned her MS in Public Health (2002) and PhD in Epidemiology (2006) from the University of Colorado Health Sciences Center and has been a faculty member in Population Health Sciences at UW-Madison since 2007.

Select, recent publications. Engelman Lab members shown in bold. A comprehensive list of Dr. Engelman’s publications can be found on her NCBI Bibliography

  • Daniel J Panyard, Lianne M Reus, Muhammad Ali, Jihua Liu, Yuetiva K Deming, Qiongshi Lu, Gwendlyn Kollmorgen, Margherita Carboni, Norbert Wild, Pieter J Visser, Lars Bertram, Henrik Zetterberg, Kaj Blennow, Johan Gobom, Dan Western, Yun Ju Sung, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Carlos Cruchaga, Betty M Tijms, Corinne D Engelman, & Michael P Snyder (2024). Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer’s disease highlights a potential role for GPX3.. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 20, 5044-5053.
  • Yuexuan Xu, Zhongxuan Sun, Erin Jonaitis, Yuetiva Deming, Qiongshi Lu, Sterling C Johnson, & Corinne D Engelman (2024). Apolipoprotein E moderates the association between non-APOE polygenic risk score for Alzheimer’s disease and aging on preclinical cognitive function.. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 20, 1063-1075.
  • Yuexuan Xu, Eva Vasiljevic, Yuetiva K Deming, Erin M Jonaitis, Rebecca L Koscik, Carol A Van Hulle, Qiongshi Lu, Margherita Carboni, Gwendlyn Kollmorgen, Norbert Wild, Cynthia M Carlsson, Sterling C Johnson, Henrik Zetterberg, Kaj Blennow, & Corinne D Engelman (2023). Effect of Pathway-Specific Polygenic Risk Scores for Alzheimer’s Disease (AD) on Rate of Change in Cognitive Function and AD-Related Biomarkers Among Asymptomatic Individuals.. Journal of Alzheimer’s disease : JAD, 94, 1587-1605.
  • Daniel J Panyard, Yuetiva K Deming, Burcu F Darst, Carol A Van Hulle, Henrik Zetterberg, Kaj Blennow, Gwendlyn Kollmorgen, Ivonne Suridjan, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Corinne D Engelman, & Qiongshi Lu (2023). Liver-Specific Polygenic Risk Score Is Associated with Alzheimer’s Disease Diagnosis.. Journal of Alzheimer’s disease : JAD, 92, 395-409.
  • Daniel J Panyard, Justin McKetney, Yuetiva K Deming, Autumn R Morrow, Gilda E Ennis, Erin M Jonaitis, Carol A Van Hulle, Chengran Yang, Yun Ju Sung, Muhammad Ali, Gwendlyn Kollmorgen, Ivonne Suridjan, Anna Bayfield, Barbara B Bendlin, Henrik Zetterberg, Kaj Blennow, Carlos Cruchaga, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Joshua J Coon, & Corinne D Engelman (2023). Large-scale proteome and metabolome analysis of CSF implicates altered glucose and carbon metabolism and succinylcarnitine in Alzheimer’s disease.. Alzheimer’s & dementia : the journal of the Alzheimer’s Association.
  • Eva Vasiljevic, Rebecca Langhough Koscik, Erin Jonaitis, Tobey Betthauser, Sterling C Johnson, & Corinne D Engelman (2023). Cognitive trajectories diverge by genetic risk in a preclinical longitudinal cohort.. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 19, 3108-3118.
  • Yuetiva Deming, Eva Vasiljevic, Autumn Morrow, Jiacheng Miao, Carol Van Hulle, Erin Jonaitis, Yue Ma, Vanessa Whitenack, Gwendlyn Kollmorgen, Norbert Wild, Ivonne Suridjan, Leslie M. Shaw, Sanjay Asthana, Cynthia M. Carlsson, Sterling C. Johnson, Henrik Zetterberg, Kaj Blennow, Barbara B. Bendlin, Qiongshi Lu, & Corinne D. Engelman (2023). Neuropathology‐basedAPOE genetic risk score better quantifies Alzheimer’s risk. Alzheimer’s & Dementia, 19, 3406-3416.
  • Ruocheng Dong, Qiongshi Lu, Hyunseung Kang, Ivonne Suridjan, Gwendlyn Kollmorgen, Norbert Wild, Yuetiva Deming, Carol A. Van Hulle, Rozalyn M. Anderson, Henrik Zetterberg, Kaj Blennow, Cynthia M. Carlsson, Sanjay Asthana, Sterling C. Johnson, & Corinne D. Engelman (2023). CSF metabolites associated with biomarkers of Alzheimer’s disease pathology. Frontiers in Aging Neuroscience, 15.
  • Daniel J Panyard, Justin McKetney, Yuetiva K Deming, Autumn R Morrow, Gilda E Ennis, Erin M Jonaitis, Carol A Van Hulle, Chengran Yang, Yun Ju Sung, Muhammad Ali, Gwendlyn Kollmorgen, Ivonne Suridjan, Anna Bayfield, Barbara B Bendlin, Henrik Zetterberg, Kaj Blennow, Carlos Cruchaga, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Joshua J Coon, & Corinne D Engelman (2023). Large-scale proteome and metabolome analysis of CSF implicates altered glucose and carbon metabolism and succinylcarnitine in Alzheimer’s disease.. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 19, 5447-5470.
  • Jerome J Choi, Rebecca L Koscik, Erin M Jonaitis, Daniel J Panyard, Autumn R Morrow, Sterling C Johnson, Corinne D Engelman, & Lauren L Schmitz (2023). Assessing the Biological Mechanisms Linking Smoking Behavior and Cognitive Function: A Mediation Analysis of Untargeted Metabolomics.. Metabolites, 13.
  • Yuetiva Deming, Eva Vasiljevic, Autumn Morrow, Jiacheng Miao, Carol Van Hulle, Erin Jonaitis, Yue Ma, Vanessa Whitenack, Gwendlyn Kollmorgen, Norbert Wild, Ivonne Suridjan, Leslie M Shaw, Sanjay Asthana, Cynthia M Carlsson, Sterling C Johnson, Henrik Zetterberg, Kaj Blennow, Barbara B Bendlin, Qiongshi Lu, Corinne D Engelman, & Alzheimer’s Disease Neuroimaging Initiative (2023). Neuropathology-based APOE genetic risk score better quantifies Alzheimer’s risk.. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 19, 3406-3416.
  • Autumn Morrow, Daniel J Panyard, Yuetiva K Deming, Erin Jonaitis, Ruocheng Dong, Eva Vasiljevic, Tobey J Betthauser, Gwendlyn Kollmorgen, Ivonne Suridjan, Anna Bayfield, Carol A Van Hulle, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Sanjay Asthana, Sterling C Johnson, & Corinne D Engelman (2022). Cerebrospinal Fluid Sphingomyelins in Alzheimer’s Disease, Neurodegeneration, and Neuroinflammation.. Journal of Alzheimer’s disease : JAD, 90, 667-680.
  • Ruocheng Dong, Diandra N Denier-Fields, Qiongshi Lu, Ivonne Suridjan, Gwendlyn Kollmorgen, Norbert Wild, Tobey James Betthauser, Cynthia M Carlsson, Sanjay Asthana, Sterling C Johnson, Henrik Zetterberg, Kaj Blennow, & Corinne D Engelman (2022). Principal components from untargeted cerebrospinal fluid metabolomics associated with Alzheimer’s disease biomarkers.. Neurobiology of aging, 117, 12-23.
  • Burcu F Darst, Zhiguang Huo, Erin M Jonaitis, Rebecca L Koscik, Lindsay R Clark, Qiongshi Lu, William S Kremen, Carol E Franz, Brinda Rana, Michael J Lyons, Kirk J Hogan, Jinying Zhao, Sterling C Johnson, & Corinne D Engelman (2021). Metabolites Associated with Early Cognitive Changes Implicated in Alzheimer’s Disease.. Journal of Alzheimer’s disease : JAD, 79, 1041-1054.
  • Daniel J Panyard, Kyeong Mo Kim, Burcu F Darst, Yuetiva K Deming, Xiaoyuan Zhong, Yuchang Wu, Hyunseung Kang, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Corinne D Engelman, & Qiongshi Lu (2021). Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations.. Communications biology, 4, 63.
  • Justin McKetney, Daniel J Panyard, Sterling C Johnson, Cynthia M Carlsson, Corinne D Engelman, & Joshua J Coon (2021). Pilot proteomic analysis of cerebrospinal fluid in Alzheimer’s disease.. Proteomics. Clinical applications, 15, e2000072.
  • Kathryn E Hatchell, Qiongshi Lu, Julie A Mares, Erin D Michos, Alexis C Wood, & Corinne D Engelman (2020). Multi-ethnic analysis shows genetic risk and environmental predictors interact to influence 25(OH)D concentration and optimal vitamin D intake.. Genetic epidemiology, 44, 208-217.
  • Burcu F. Darst, Rebecca L. Koscik, Kirk J. Hogan, Sterling C. Johnson, & Corinne D. Engelman (2019). Longitudinal plasma metabolomics of aging and sex. Aging, 11, 1262-1282.
  • Burcu F Darst, Qiongshi Lu, Sterling C Johnson, & Corinne D Engelman (2019). Integrated analysis of genomics, longitudinal metabolomics, and Alzheimer’s risk factors among 1,111 cohort participants.. Genetic epidemiology, 43, 657-674.*Eva Vasiljevic, Zhan Ye, Derek M Pavelec, Burcu F Darst, Corinne D Engelman, & Mei W Baker (2019). Carrier frequency estimation of Zellweger spectrum disorder using ExAC database and bioinformatics tools.. Genetics in medicine : official journal of the American College of Medical Genetics, 21, 1969-1976.
  • Kathryn E Hatchell, Qiongshi Lu, Scott J Hebbring, Erin D Michos, Alexis C Wood, & Corinne D Engelman (2019). Ancestry-specific polygenic scores and SNP heritability of 25(OH)D in African- and European-ancestry populations.. Human genetics, 138, 1155-1169.

Her research focuses on the study design and data analysis of genetic, demographic, socioeconomic, behavioral, physiological and environmental factors of complex diseases, especially biomarkers and preclinical traits related to Alzheimer’s disease. Dr. Engelman’s group uses epidemiological, statistical, and bioinformatic approaches to analyze large-scale ‘omic data, including that from whole genome array genotyping; whole-genome sequencing; and metabolomic, lipidomic, and proteomic mass spectrometry. Her research integrates ‘omic and questionnaire data to understand, predict, prevent, and/or treat health conditions. Dr. Engelman is especially interested in identifying interactions with modifiable factors (e.g., social, behavioral, and environmental) to inform precision medicine and health.

Courses Taught

  • NUTR SCI 375: Introduction to Epidemiology
  • POP HLTH 636: Public Health Genomics
  • POP HLTH 849: Genetic Epidemiology

Affiliations/Associations

  • American Society of Human Genetics
  • International Genetic Epidemiology Soceity
  • International Society to Advance Alzheimer Research and Treatment
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