Degree and area of specialization:Ph.D. or MD/PHD. required in the biochemical sciences with an emphasis on either biochemistry, cell biology, immunology or genetics.

 

Minimum number of years and type of relevant work experience:Recent Ph.Ds as well as experienced candidates are welcomed to apply. Research experience in at least one of the following areas required: molecular biology, biochemistry, cell biology, genetics or immunology. Experience or willingness to work with transgenic mouse colonies is required.  Expertise in one or the more of following skills/techniques is highly desired.

Immunofluorescence/immunohistochemistry, fluorescence or confocal imaging, mammalian cell culture, RNA and protein work, multicolor FACS analysis, mouse models of disease/autoimmunity, and prior experience on handling large data sets (RNAseq, proteomics).

 

Position Summary:The Engin Laboratory is focused on understanding the role of the unfolded protein response (UPR) signaling pathway in beta cell dysfunction and diabetes. The work involves working with the tissue specific mouse models of the UPR pathway and mechanistic studies using cell culture, imaging, biochemical and immunological assays. More information about our research and publications can be found at enginlab.org.

The ideal candidate is expected to be a creative, productive and self-motivated individual with the ability to think critically, learn quickly and function both independently and within a team.

 

Principal duties:The candidate will investigate the molecular mechanisms of beta cell failure in diabetes in the Engin Lab. The candidate is expected to design and implement strategies to investigate the unfolded protein response in beta cells of recently generated transgenic mouse models of diabetes. He/she is also expected to explore new research areas and seek independent funding as part of their own career development. He/she will 1) assist in the execution of ongoing projects by performing experiments and analyzing data 2) develop novel ideas in line with the projects in the lab, 3) provide training/mentoring to graduate and undergraduate students 4) attend national and international meetings to present data, 5) help Dr. Engin with writing and preparing grants and manuscripts.

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