John Hollander, PhD

The mitochondrion is an important organelle that is tasked with a multitude of functions requisite for cellular viability. As such, pathological influence on the mitochondrion remains at the forefront of research efforts focused on treating morbidity and mortality resulting from a multitude of disease states, including those influencing the cardiovascular system. Mechanistic evaluation of cardiovascular disease continues to suggest a central role for the mitochondrion, thus, understanding its contribution to the development and progression of cardiac pathologies is critical as we consider therapeutic options. The research in our laboratory focuses on understanding how different physiological and pathological states impact mitochondrial function, with the ultimate goal of developing therapeutic interventions designed to limit dysfunction to this critical organelle.