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Assistant Professor of Nutritional Sciences
B.S. 2002, University of Virginia’s College at Wise
Ph.D. 2008, University of Alabama, Birmingham
Assistant Professor of Nutritional Sciences
B.S. 2002, University of Virginia’s College at Wise
Ph.D. 2008, University of Alabama, Birmingham
- Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males
- Physiological consequences of Aldolase C deficiency during lactation
- Liver-specific deletion of Agpat5 protects against liquid sucrose-induced hyperinsulinemia and glucose intolerance
- Mining cholesterol genes from thousands of mouse livers identifies aldolase C as a regulator of cholesterol biosynthesis
- Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin
- Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 ( <em>Abhd2</em> ) as an enzyme that metabolizes phosphatidylcholine and cardiolipin
- "Humanizing" mouse environments: Humidity, diurnal cycles and thermoneutrality
- Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake
- Cross-species data integration to prioritize causal genes in lipid metabolism
- Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis
The Parks Lab is focused on addressing the question of how genetics and diet interact together to contribute to common metabolic diseases, such as obesity and diabetes. Through the use of large-scale integrative genetic studies in the mouse we have identified several candidate genes that mediate gene-diet interactions. Current work is focused on a novel candidate drug target, Agpat5, which improves common symptoms of obesity and diabetes. In addition to this work we have a strong interest in the development of systems genetics approaches for dissecting biological pathways and networks.