Assistant Professor of Nutritional Sciences
BS 2007, Gonzaga University
PhD 2012, Oregon State University
Caloric restriction, metabolism, biology of aging, systems biology, gene expression regulation
Work in the GERAM (Gene Expression Regulation of Aging and Metabolism) lab, directed by Dr. Rhoads, focuses on understanding the molecular regulation of aging and metabolism through the use of caloric restriction (CR). CR is a dietary intervention and model of delayed aging; CR results in extended lifespan in numerous model organisms. This is of direct relevance for human health, as advanced age is the largest risk factor for numerous chronic diseases – cancer, diabetes, cardiovascular disease, and neurodegeneration, to name a few. However, the molecular mechanisms connecting reduced caloric intake with enhanced longevity and reduced chronic disease vulnerability remain poorly understood. The GERAM lab focuses on mechanisms of gene expression regulation, including protein post-translational modification, mRNA processing, and expression regulation via endogenous small RNA. Tools used include both wet lab and dry lab analytical methods, with a substantial interest in integrative models that produce systems-level insights.
Rhoads TW, Burhans MS, Chen VB, Hutchins PD, Rush MJP, Clark JP, Stark JL, McIlwain SJ, Eghbalnia HR, Pavelec DM, Ong IM, Denu JM, Markley JL, Coon JJ, Colman RJ, Anderson RM. “Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys.” Cell Metabolism 2018 Mar; 27(3):677-688. PMID: 29514073.
Rhoads TW, Clark JP, Gustafson GE, Miller KN, Conklin MW, DeMuth TM, Berres ME, Eliceiri KW, Vaughan LK, Lary CW, Beasley TM, Colman RJ, Anderson RM. “Molecular and Functional Networks Linked to Sarcopenia Prevention by Caloric Restriction in Rhesus Monkeys.” Cell Systems 2020 Feb; 10(2):156-168. PMID: 31982367.
Dieterich IA, Lawton AJ, Peng Y, Yu Q, Rhoads TW, Overmyer KA, Cui Y, Armstrong EA, Howell PR, Burhans MS, Li L, Denu JM, Coon JJ, Anderson RM, Puglielli L. “Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk.” Nature Communications 2019 Sep; 10(1): 3929. PMID: 31477734.
Smith AB, Schill JP, Gordillo R, Gustafson GE, Rhoads TW, Burhans MS, Broman AT, Colman RJ, Scherer PE, Anderson RM. “Ceramides are early responders in metabolic syndrome development in rhesus monkeys.” Scientific Reports 2022 Jun; 12(1): 9960. PMID: 35705631.
Hoskins AA, Rhoads TW. “When cells are down on their LUC7L2, alternative splicing rewires metabolism for OXPHOS.” Molecular Cell 2021 May; 81(9):1859-1860. PMID: 33961773.
Rhoads TW, Prasad A, Kwiecien NW, Merrill AE, Zawack K, Westphall MS, Schroeder FC, Kimble J, Coon JJ. “NeuCode Labeling in Nematodes: Proteomic and Phosphoproteomic Impact of Ascaroside Treatment in Caenorhabditis elegans.” Molecular & Cellular Proteomics 2015 Nov; 14(11): 2922-2935. PMID: 26392051.
Rhoads TW, Anderson RM. “Taking the long view on metabolism.” Science 2021 Aug; 373(6556):738-739. PMID: 34385381.
Full Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/timothy.rhoads.1/bibliography/public/