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Madison, WI 53706

Investigator – Morgridge Institute for Research
Ph.D. 2014, Princeton University
- Label-free metabolic imaging monitors the fitness of chimeric antigen receptor T cells
- Single cell autofluorescence imaging reveals immediate metabolic shifts of neutrophils with activation across biological systems
- Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide
- Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response
- Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue
- Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response
- GATA1-deficient human pluripotent stem cells generate neutrophils with improved antifungal immunity that is mediated by the integrin CD18
- Physiological consequences of Aldolase C deficiency during lactation
- Metabolic modulation of melanoma enhances the therapeutic potential of immune checkpoint inhibitors
- GATA1-deficient human pluripotent stem cells generate neutrophils with improved antifungal immunity that is mediated by the integrin CD18
Mammalian cellular metabolism is a dynamic process that consists of thousands of interconnected reactions and regulatory interactions. While the architecture of metabolic networks is defined by the genome, actual metabolic activity through the pathways varies greatly. Dynamic reprogramming of metabolism enables cells to meet metabolic needs associated with specific cellular states and cellular functions (such as supporting proliferation or activating immune function), and adapt to changes in the environment. The overarching goal of my research is to understand how mammalian cellular metabolism is reprogrammed in response to changes in the environment and cellular state, and how key metabolic activities in turn affect cell physiology. To study this, I combine systematic approaches, especially metabolomics, lipidomics and fluxomics, with targeted biochemical and genetic techniques. Currently, my lab focuses on two main areas: (1) understanding how metabolic reprogramming affects the inflammatory state in macrophages and neutrophils, and (2) understanding how specific conditions in the tumor microenvironment impact the metabolism and behavior of immune cells and cancer cells.