
Assistant Professor of Nutritional Sciences
BS 2007, Gonzaga University
PhD 2012, Oregon State University
- Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys
- Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism
- Caloric restriction reprograms adipose tissues in rhesus monkeys
- Neuron-specific isoform of PGC-1α regulates neuronal metabolism and brain aging
- Geroprotector drugs and exercise: friends or foes on healthy longevity?
- Mitochondrial regulator PGC-1a in neuronal metabolism and brain aging
- The Third Annual Symposium of the Midwest Aging Consortium
- Ceramides are early responders in metabolic syndrome development in rhesus monkeys
- Caloric restriction has a new player
- Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49<sup>th</sup> Annual Meeting of the American Aging Association
Work in the GERAM (Gene Expression Regulation of Aging and Metabolism) lab, directed by Dr. Rhoads, focuses on understanding the molecular regulation of aging and metabolism through the use of caloric restriction (CR). CR is a dietary intervention and model of delayed aging; CR results in extended lifespan in numerous model organisms. This is of direct relevance for human health, as advanced age is the largest risk factor for numerous chronic diseases – cancer, diabetes, cardiovascular disease, and neurodegeneration, to name a few. However, the molecular mechanisms connecting reduced caloric intake with enhanced longevity and reduced chronic disease vulnerability remain poorly understood. The GERAM lab focuses on mechanisms of gene expression regulation, including protein post-translational modification, mRNA processing, and expression regulation via endogenous small RNA. Tools used include both wet lab and dry lab analytical methods, with a substantial interest in integrative models that produce systems-level insights.